PDF DatasheetHuman Midkine / MDK Protein Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant Midkine / MDK Protein based upon sequence from: Human
Host: QP10419 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human Midkine / MDK Protein, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10419.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The biological activity determined by a chemotaxis bioassay using human neutrophils is in a concentration range of 0.1-10 ng/ml.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: VAKKKDKVKK GGPGSECAEW AWGPCTPSSK DCGVGFREGT CGAQTQRIRC RVPCNWKKEF GADCKYKFEN WGACDGGTGT KVRQGTLKKA RYNAQCQETI RVTKPCTPKT KAKAKAKKGK GKD
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human Midkine / MDK Protein Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Midkine / MDK Protein Protein General Information | |
|---|---|
| Alternate Names | |
| Midkine; MDK Protein; MK; NEGF2; ARAP | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | MDK |
| Entrez Gene ID | 4192 |
| Ensemble Gene ID | ENSG00000110492 |
| RefSeq Protein Accession(s) | NP_001012333.1 |
| RefSeq mRNA Accession(s) | NM_001012333.2, NM_001012334.2, NM_001270550.1, NM_001270551.1, NM_001270552.1, NM_002391.4, XM_011520116.2, XM_017017764.1 |
| UniProt ID(s) | P21741 |
| UniGene ID(s) | Hs.82045 |
| HGNC ID(s) | HGNC:6972 |
| COSMIC ID Link(s) | MDK |
| KEGG Gene ID(s) | hsa:4192 |
| PharmGKB ID(s) | PA30717 |
| General Description of Recombinant Human Midkine / MDK Protein Protein. | |
| Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity). | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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