PDF DatasheetHuman NRG1 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant NRG1 based upon sequence from: Human
Host: QP10420 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human NRG1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10420.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by a cell proliferation assay using serum free human MCF-7 cells is less than 40 ng/ml, corresponding to a specific activity of > 2.5 × 104 IU/mg.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCQPGF TGARCTENVP MKVQNQEKAE ELYQK
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human NRG1 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 m filtered 20 mM PBS, pH 6.0, 150 mM NaCl, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human NRG1 Protein General Information | |
|---|---|
| Alternate Names | |
| NRG1; GGF; GGF2; HGL; HRGA; MSTP131; NDF; HRG; HRG1; MST131; NRG1-IT2; ARIA; SMDF | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | NRG1 |
| Entrez Gene ID | 3084 |
| Ensemble Gene ID | ENSG00000157168 |
| RefSeq Protein Accession(s) | NP_001153467.1 |
| RefSeq mRNA Accession(s) | NM_001159995.2, NM_001159999.2, NM_001160001.2, NM_001160005.1, NM_001160008.1, NM_001322205.1, NM_001322206.1, NM_001322207.1, NM_013956.4, NM_013957.4, NM_013958.3, NM_013959.3, NM_013960.4, NM_013962.2, NM_013964.4 |
| UniProt ID(s) | Q02297 |
| HGNC ID(s) | HGNC:7997 |
| COSMIC ID Link(s) | NRG1 |
| KEGG Gene ID(s) | hsa:3084 |
| PharmGKB ID(s) | PA31776 |
| General Description of Recombinant Human NRG1 Protein. | |
| Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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