PDF DatasheetHuman Osteoprotegerin / TNFRSF11B Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant Osteoprotegerin / TNFRSF11B based upon sequence from: Human
Host: QP10426 protein expressed in Yeast.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human Osteoprotegerin / TNFRSF11B, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10426.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by neutralizing the stimulation of U937 cells is less than 10 ng/ml, corresponding to a specific activity of > 1.0 × 105 IU/mg in the presence of 10 ng/mL soluble rHuRANKL (sRANKL).
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: ETFPPKYLHY DEETSHQLLC DKCPPGTYLK QHCTAKWKTV CAPCPDHYYT DSWHTSDECL YCSPVCKELQ YVKQECNRTH NRVCECKEGR YLEIEFCLKH RSCPPGFGVV QAGTPERNTV CKRCPDGFFS NETSSKAPCR KHTNCSVFGL LLTQKGNATH DNICSGNSES TQKCGIDVTL EPKSSDKTHT CPPCPAPEFE GAPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPTPIEKT ISKAKGQPRE PQVYTLPPSR DELTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GK
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human Osteoprotegerin / TNFRSF11B Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2um filtered 20 mM PBS, pH 6.0, 150 mM NaCl, 0.02 % Tween-80, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Osteoprotegerin / TNFRSF11B Protein General Information | |
|---|---|
| Alternate Names | |
| Osteoprotegerin; TNFRSF11B; PDB5; OCIF; OPG; TR1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TNFRSF11B |
| Entrez Gene ID | 4982 |
| Ensemble Gene ID | ENSG00000164761 |
| RefSeq Protein Accession(s) | NP_002537.3 |
| RefSeq mRNA Accession(s) | NM_002546.3 |
| UniProt ID(s) | O00300 |
| HGNC ID(s) | HGNC:11909 |
| COSMIC ID Link(s) | TNFRSF11B |
| KEGG Gene ID(s) | hsa:4982 |
| PharmGKB ID(s) | PA36602 |
| General Description of Recombinant Human Osteoprotegerin / TNFRSF11B Protein. | |
| Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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