PDF DatasheetHuman Noggin / NOG Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant Noggin / NOG based upon sequence from: Human
Host: QP10428 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human Noggin / NOG, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10428.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by inhibiting BMP-4- induced alkaline phosphatase production of murine ATDC5 cells is less than 3.0 ng/ml, corresponding to a specific activity of > 3.3 × 105 IU/mg in the presence of 5 ng/ml rHuBMP-4.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: MQHYLHIRPA PSDNLPLVDL IEHPDPIFDP KEKDLNETLL RSLLGGHYDP GFMATSPPED RPGGGGGAAG GAEDLAELDQ LLRQRPSGAM PSEIKGLEFS EGLAQGKKQR LSKKLRRKLQ MWLWSQTFCP VLYAWNDLGS RFWPRYVKVG SCFSKRSCSV PEGMVCKPSK SVHLTVLRWR CQRRGGQRCG WIPIQYPIIS ECKCSC
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human Noggin / NOG Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered 30 % acetonitrile, 0.1 % TFA, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Noggin / NOG Protein General Information | |
|---|---|
| Alternate Names | |
| Noggin; NOG; SYNS1; SYNS1A; SYM1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | NOG |
| Entrez Gene ID | 9241 |
| Ensemble Gene ID | ENSG00000183691 |
| RefSeq Protein Accession(s) | NP_005441.1 |
| RefSeq mRNA Accession(s) | NM_005450.4 |
| UniProt ID(s) | Q13253 |
| HGNC ID(s) | HGNC:7866 |
| COSMIC ID Link(s) | NOG |
| KEGG Gene ID(s) | hsa:9241 |
| PharmGKB ID(s) | PA31670 |
| General Description of Recombinant Human Noggin / NOG Protein. | |
| Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 (PubMed:21976273). | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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