PDF DatasheetHuman sIL 6R Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant sIL 6R based upon sequence from Human
Host: QP13504 protein expressed in E. Coli.
Available Tags: His
Protein Construction: A cDNA sequence encoding the sequence of sIL 6R was constructred and used to recombinantly synthesize the protein.
Recommended Applications: See Application Notes
Application Notes: Please contact us for application specific information for QP13504.
Bioactivity Data: Untested
Amino Acid Sequence: MLAVGCALLA ALLAAPGAAL APRRCPAQEV ARGVLTSLPG DSVTLTCPGV EPEDNATVHW VLRKPAAGSH PSRWAGMGRR LLLRSVQLHD SGNYSCYRAG RPAGTVHLLV DVPPEEPQLS CFRKSPLSNV VCEWGPRSTP SLTTKAVLLV RKFQNSPAED FQEPCQYSQE SQKFSCQLAV PEGDSSFYIV SMCVASSVGS KFSKTQTFQG CGILQPDPPA NITVTAVARN PRWLSVTWQD PHSWNSSFYR LRFELRYRAE RSKTFTTWMV KDLQHHCVIH DAWSGLRHVV QLRAQEEFGQ GEWSEWSPEA MGTPWTESRS PPAENEVSTP MQALTTNKDD DNILFRDSAN ATSLPVQDSS SVPLPTFLVA GGSLAFGTLL CIAIVLRFKK TWKLRALKEG KTSMHPPYSL GQLVPERPRP TPVLVPLISP PVSPSSLGSD NTSSHNRPDA RDPRSPYDIS NTDYFFPR
Purity: Greater than 90.0% as determined by SDS-PAGE.
Reconstitution Instructions: |||
Endotoxin Levels: Not Determined. Testing recommended prior to use in cell culture and can be performed upon request.
Buffer: CD126 His-Tag protein is supplied in 20mM Tris-HCl, pH 8.0, 0.8M Urea & 50% glycerol.
Storage Conditions: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
Physical Appearance: Sterile Filtered clear solution.
| Recombinant Human sIL 6R General Information | |
|---|---|
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| Alternate Names | |
| IL6R-alpha, CD126, IL-6R 1, CD126 antigen, IL6RA, Interleukin 6 receptor, Interleukin 6 receptor alpha subunit, Interleukin-6 receptor alpha chain precursor, B cell stimulatory factor-2,Membrane glycoprotein 80, gp80, IL-6R, MGC104991. | |
| Molecular Weight | |
| 42.25 kDa | |
| Chromosomal Location | |
| q21.3 on chromosome 1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IL6R |
| Entrez Gene ID | 3570 |
| UniProt ID(s) | P08887 |
| COSMIC ID Link(s) | IL6R |
| KEGG Gene ID(s) | hsa:3570 |
| General Description of Recombinant Human sIL 6R. | |
| Human sIL-6R produced in E. Coli is a single, non-glycosylated polypeptide chain containing 338 amino acids (20-357) corresponding to the mature IL-6R protein, having a molecular weight of 42.25 kDa, with an amino terminal hexahistidine tag. The sIL6R is purified by using an optimized multi-step FPLC method for maximum separation from contaminants. | |
Selected References
IL-6 loss causes ventriculardysfunction, fibrosis, reduced capillary density, and dramatically alters thecell populations of the developing and adult heartPublication: American Journal of Physiology-Heart andCirculatory Physiology 296.5 (2009): H1694-H1704.Link: http://ajpheart.physiology.org/content/296/5/H1694.short
Limitations and Performance Guarantee
enQuire Bio’s products are guaranteed and approved for RESEARCH USE ONLY or manufacturing purposes. This product may not be used as a pharmaceutical agent, or other product intended for human consumption without meeting additional regulatory requirements. This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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