PDF DatasheetHuman F-box only protein 2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant F-box only protein 2 based upon sequence from Human
Host: QP5600 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) F-box only protein 2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5600.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Pro296
Amino Acid Sequence: MDGDGDPESV GQPEEASPEE QPEEASAEEE RPEDQQEEEA AAAAAYLDEL PEPLLLRVLA ALPAAELVQA CRLVCLRWKE LVDGAPLWLL KCQQEGLVPE GGVEEERDHW QQFYFLSKRR RNLLRNPCGE EDLEGWCDVE HGGDGWRVEE LPGDSGVEFT HDESVKKYFA SSFEWCRKAQ VIDLQAEGYW EELLDTTQPA IVVKDWYSGR SDAGCLYELT VKLLSEHENV LAEFSSGQVA VPQDSDGGGW MEISHTFTDY GPGVRFVRFE HGGQDSVYWK GWFGARVTNS SVWVEP
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human F-box only protein 2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human F-box only protein 2 Protein General Information | |
|---|---|
| Alternate Names | |
| FBX2, FBG1, Fbs1, NFB42, OCP1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | FBXO2 |
| Entrez Gene ID | 26232 |
| Ensemble Gene ID | ENSG00000116661 |
| RefSeq Protein Accession(s) | NP_036300.2 |
| RefSeq mRNA Accession(s) | NM_012168.5 |
| UniProt ID(s) | Q9UK22 |
| UniGene ID(s) | Hs.132753 |
| HGNC ID(s) | HGNC:13581 |
| COSMIC ID Link(s) | FBXO2 |
| KEGG Gene ID(s) | hsa:26232 |
| PharmGKB ID(s) | PA31895 |
| General Description of Recombinant Human F-box only protein 2 Protein. | |
| Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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