PDF DatasheetHuman Angiotensinogen / SerpinA8 / AGT Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Angiotensinogen / SerpinA8 / AGT based upon sequence from Human
Host: QP5624 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Angiotensinogen / SerpinA8 / AGT, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5624.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Val44 – Ser427
Amino Acid Sequence: VIHNESTCEQ LAKANAGKPK DPTFIPAPIQ AKTSPVDEKA LQDQLVLVAA KLDTEDKLRA AMVGMLANFL GFRIYGMHSE LWGVVHGATV LSPTAVFGTL ASLYLGALDH TADRLQAILG VPWKDKNCTS RLDAHKVLSA LQAVQGLLVA QGRADSQAQL LLSTVVGVFT APGLHLKQPF VQGLALYTPV VLPRSLDFTE LDVAAEKIDR FMQAVTGWKT GCSLMGASVD STLAFNTYVH FQGKMKGFSL LAEPQEFWVD NSTSVSVPML SGMGTFQHWS DIQDNFSVTQ VPFTESACLL LIQPHYASDL DKVEGLTFQQ NSLNWMKKLS PRTIHLTMPQ LVLQGSYDLQ DLLAQAELPA ILHTELNLQK LSNDRIRVGE VLNS
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Angiotensinogen / SerpinA8 / AGT Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Angiotensinogen / SerpinA8 / AGT Protein General Information | |
|---|---|
| Alternate Names | |
| Angiotensinogen, SerpinA8, AGT, AI265500, AngI, Serpina8, AngII, Aogen | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | AGT |
| Entrez Gene ID | 183 |
| Ensemble Gene ID | ENSG00000135744 |
| RefSeq Protein Accession(s) | NP_000020.1 |
| RefSeq mRNA Accession(s) | NM_000029.3 |
| UniProt ID(s) | P01019 |
| UniGene ID(s) | Hs.19383 |
| HGNC ID(s) | HGNC:333 |
| COSMIC ID Link(s) | AGT |
| KEGG Gene ID(s) | hsa:183 |
| PharmGKB ID(s) | PA42 |
| General Description of Recombinant Human Angiotensinogen / SerpinA8 / AGT Protein. | |
| Essential component of the renin-angiotensin syst (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous syst, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.Angiotensin-3: stimulates aldosterone release.Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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