PDF DatasheetHuman Aldehyde oxidase Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Aldehyde oxidase based upon sequence from Human
Host: QP5656 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Aldehyde oxidase, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5656.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Phe236 – Lys421
Amino Acid Sequence: FGSERMMWFS PVTLKELLEF KFKYPQAPVI MGNTSVGPEV KFKGVFHPVI ISPDRIEELS VVNHAYNGLT LGAGLSLAQV KDILADVVQK LPEEKTQMYH ALLKHLGTLA GSQIRNMASL GGHIISRHPD SDLNPILAVG NCTLNLLSKE GKRQIPLNEQ FLSKCPNADL KPQEILVSVN IPYSRK
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Aldehyde oxidase Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Aldehyde oxidase Protein General Information | |
|---|---|
| Alternate Names | |
| AOH1, AO | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | AOX1 |
| Entrez Gene ID | 316 |
| Ensemble Gene ID | ENSG00000138356 |
| RefSeq Protein Accession(s) | NP_001150.3 |
| RefSeq mRNA Accession(s) | NM_001159.3 |
| UniProt ID(s) | Q06278 |
| UniGene ID(s) | Hs.406238 |
| HGNC ID(s) | HGNC:553 |
| COSMIC ID Link(s) | AOX1 |
| KEGG Gene ID(s) | hsa:316 |
| PharmGKB ID(s) | PA24842 |
| General Description of Recombinant Human Aldehyde oxidase Protein. | |
| Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and N-methylphthalazinium, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.