PDF DatasheetHuman ATPase ASNA1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant ATPase ASNA1 based upon sequence from Human
Host: QP5685 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) ATPase ASNA1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5685.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ala2 – Gln348
Amino Acid Sequence: AAGVAGWGVE AEEFEDAPDV EPLEPTLSNI IEQRSLKWIF VGGKGGVGKT TCSCSLAVQL SKGRESVLII STDPAHNISD AFDQKFSKVP TKVKGYDNLF AMEIDPSLGV AELPDEFFEE DNMLSMGKKM MQEAMSAFPG IDEAMSYAEV MRLVKGMNFS VVVFDTAPTG HTLRLLNFPT IVERGLGRLM QIKNQISPFI SQMCNMLGLG DMNADQLASK LEETLPVIRS VSEQFKDPEQ TTFICVCIAE FLSLYETERL IQELAKCKID THNIIVNQLV FPDPEKPCKM CEARHKIQAK YLDQMEDLYE DFHIVKLPLL PHEVRGADKV NTFSALLLEP YKPPSAQ
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human ATPase ASNA1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human ATPase ASNA1 Protein General Information | |
|---|---|
| Alternate Names | |
| ARSA1, ARSA-I, ASNA-I, TRC40, GET3 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ASNA1 |
| Entrez Gene ID | 439 |
| Ensemble Gene ID | ENSG00000198356 |
| RefSeq Protein Accession(s) | NP_004308.2 |
| RefSeq mRNA Accession(s) | NM_004317.3 |
| UniProt ID(s) | O43681 |
| UniGene ID(s) | Hs.465985 |
| HGNC ID(s) | HGNC:752 |
| COSMIC ID Link(s) | ASNA1 |
| KEGG Gene ID(s) | hsa:439 |
| PharmGKB ID(s) | PA25051 |
| General Description of Recombinant Human ATPase ASNA1 Protein. | |
| ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmbrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by mbrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA mbrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the mbrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting . May be involved in insulin signaling. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.