PDF DatasheetHuman Asporin Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Asporin based upon sequence from Human
Host: QP5687 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Asporin, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5687.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Asp33 – Met380
Amino Acid Sequence: DMEDTDDDDD DDDDDDDDDE DNSLFPTREP RSHFFPFDLF PMCPFGCQCY SRVVHCSDLG LTSVPTNIPF DTRMLDLQNN KIKEIKENDF KGLTSLYGLI LNNNKLTKIH PKAFLTTKKL RRLYLSHNQL SEIPLNLPKS LAELRIHENK VKKIQKDTFK GMNALHVLEM SANPLDNNGI EPGAFEGVTV FHIRIAEAKL TSVPKGLPPT LLELHLDYNK ISTVELEDFK RYKELQRLGL GNNKITDIEN GSLANIPRVR EIHLENNKLK KIPSGLPELK YLQIIFLHSN SIARVGVNDF CPTVPKMKKS LYSAISLFNN PVKYWEMQPA TFRCVLSRMS VQLGNFGM
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Asporin Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Asporin Protein General Information | |
|---|---|
| Alternate Names | |
| PLAP-1, SLRR1C, OS3, PLAP1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ASPN |
| Entrez Gene ID | 54829 |
| Ensemble Gene ID | ENSG00000106819 |
| RefSeq Protein Accession(s) | NP_001180264.1 |
| RefSeq mRNA Accession(s) | NM_001193335.1, NM_017680.4 |
| UniProt ID(s) | Q9BXN1 |
| UniGene ID(s) | Hs.435655 |
| HGNC ID(s) | HGNC:14872 |
| COSMIC ID Link(s) | ASPN |
| KEGG Gene ID(s) | hsa:54829 |
| PharmGKB ID(s) | PA25057 |
| General Description of Recombinant Human Asporin Protein. | |
| Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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