PDF DatasheetHuman ATF2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant ATF2 based upon sequence from Human
Host: QP5688 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) ATF2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5688.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Ser505
Amino Acid Sequence: MKFKLHVNSA RQYKDLWNMS DDKPFLCTAP GCGQRFTNED HLAVHKHKHE MTLKFGPARN DSVIVADQTP TPTRFLKNCE EVGLFNELAS PFENEFKKAS EDDIKKMPLD LSPLATPIIR SKIEEPSVVE TTHQDSPLPH PESTTSDEKE VPLAQTAQPT SAIVRPASLQ VPNVLLTSSD SSVIIQQAVP SPTSSTVITQ APSSNRPIVP VPGPFPLLLH LPNGQTMPVA IPASITSSNV HVPAAVPLVR PVTMVPSVPG IPGPSSPQPV QSEAKMRLKA ALTQQHPPVT NGDTVKGHGS GLVRTQSEES RPQSLQQPAT STTETPASPA HTTPQTQSTS GRRRRAANED PDEKRRKFLE RNRAAASRCR QKRKVWVQSL EKKAEDLSSL NGQLQSEVTL LRNEVAQLKQ LLLAHKDCPV TAMQKKSGYH TADKDDSSED ISVPSSPHTE AIQHSSVSTS NGVSSTSKAE AVATSVLTQM ADQSTEPALS QIVMAPSSQS QPSGS
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human ATF2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human ATF2 Protein General Information | |
|---|---|
| Alternate Names | |
| ATF2, CREB-2, TREB7, CREB2, CRE-BP1, HB16 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ATF2 |
| Entrez Gene ID | 1386 |
| Ensemble Gene ID | ENSG00000115966 |
| RefSeq Protein Accession(s) | NP_001243019.1 |
| RefSeq mRNA Accession(s) | NM_001256090.1, NM_001256091.1, NM_001256092.1, NM_001256093.1, NM_001256094.1, NM_001880.3 |
| UniProt ID(s) | P15336 |
| UniGene ID(s) | Hs.592510 |
| HGNC ID(s) | HGNC:784 |
| COSMIC ID Link(s) | ATF2 |
| KEGG Gene ID(s) | hsa:1386 |
| PharmGKB ID(s) | PA25084 |
| General Description of Recombinant Human ATF2 Protein. | |
| Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response elent) consensus sequences (5′-TGACGTCA-3′) or to AP-1 (activator protein 1) consensus sequences (5′-TGACTCA-3′). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer mbrane, thereby impairing mitochondrial mbrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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