PDF DatasheetHuman ATF7 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant ATF7 based upon sequence from Human
Host: QP5689 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) ATF7, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5689.
Bioactivity Data: Untested
Full Length? Full Length of BC042363
Expression Region: Met1 – Gly117
Amino Acid Sequence: MGDDRPFVCN ATGCGQRFTN EDHLAVHKHK HEMTLKFGPA RTDSVIIADQ TPTPTRFLKN CEEVGLFNEL ASSFEHEFKK AADEDEKKAR SRTVAKKLVV FRPRLFLLCF GIIFLIG
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human ATF7 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human ATF7 Protein General Information | |
|---|---|
| Alternate Names | |
| ATFA, Cyclic AMP-dependent transcription factor ATF | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ATF7 |
| Entrez Gene ID | 11016 |
| Ensemble Gene ID | ENSG00000170653 |
| RefSeq Protein Accession(s) | NP_001123532.1 |
| RefSeq mRNA Accession(s) | NM_001130060.1, NM_001206682.1, NM_001206683.1, NM_006856.2, XM_005268587.3, XM_017018722.1 |
| UniProt ID(s) | P17544 |
| UniGene ID(s) | Hs.12286 |
| HGNC ID(s) | HGNC:792 |
| COSMIC ID Link(s) | ATF7 |
| KEGG Gene ID(s) | hsa:11016 |
| PharmGKB ID(s) | PA25092 |
| General Description of Recombinant Human ATF7 Protein. | |
| Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5′-GTGACGT[AG][AG]-3′), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Isoform 4 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter. Isoform 5 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation. |
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Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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