PDF DatasheetHuman BCL2L1 / Bcl-XL Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant BCL2L1 / Bcl-XL based upon sequence from Human
Host: QP5711 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) BCL2L1 / Bcl-XL, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5711.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 – Arg209
Amino Acid Sequence: MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEG TESEMETPSA INGNPSWHLA DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR YRRAFSDLTS QLHITPGTAY QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL CVESVDKEMQ VLVSRIAAWM ATYLNDHLEP WIQENGGWDT FVELYGNNAA AESRKGQER
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human BCL2L1 / Bcl-XL Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human BCL2L1 / Bcl-XL Protein General Information | |
|---|---|
| Alternate Names | |
| BCL2L1, Bcl-XL, BclX, bcl2-L-1, Bcl(X)L, Bcl2l, Bcl-XL, bcl-x | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | BCL2L1 |
| Entrez Gene ID | 598 |
| Ensemble Gene ID | ENSG00000171552 |
| RefSeq Protein Accession(s) | NP_001182.1 |
| RefSeq mRNA Accession(s) | NM_001191.3, NM_001317919.1, NM_001317920.1, NM_001317921.1, NM_001322239.1, NM_001322240.1, NM_001322242.1, NM_138578.2, XM_011528964.2, XM_017027993.1 |
| UniProt ID(s) | Q07817 |
| UniGene ID(s) | Hs.516966 |
| HGNC ID(s) | HGNC:992 |
| COSMIC ID Link(s) | BCL2L1 |
| KEGG Gene ID(s) | hsa:598 |
| PharmGKB ID(s) | PA76 |
| General Description of Recombinant Human BCL2L1 / Bcl-XL Protein. | |
| Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial mbrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial mbrane ATP synthase F1F0 activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles.Isoform Bcl-X(S) promotes apoptosis. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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