PDF DatasheetHuman Survivin / BIRC5 / API4 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Survivin / BIRC5 / API4 based upon sequence from Human
Host: QP5719 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Survivin / BIRC5 / API4, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5719.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Asp142
Amino Acid Sequence: MGAPTLPPAW QPFLkDaHRI STFKNWPFLE GCACTPERMA EAGFIHCPTE NEPDLAQCFF CFKELEGWEP DDDPIEEHKK HSSGCAFLSV KKQFEELTLG EFLKLDRERA KNKIAKETNN KKKEFEETAK KVRRAIEQLA AMD
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Survivin / BIRC5 / API4 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Survivin / BIRC5 / API4 Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | BIRC5 |
| Entrez Gene ID | 332 |
| Ensemble Gene ID | ENSG00000089685 |
| RefSeq Protein Accession(s) | NP_001012270.1 |
| RefSeq mRNA Accession(s) | NM_001012270.1, NM_001012271.1, NM_001168.2 |
| UniProt ID(s) | O15392 |
| UniGene ID(s) | Hs.744872 |
| HGNC ID(s) | HGNC:593 |
| COSMIC ID Link(s) | BIRC5 |
| KEGG Gene ID(s) | hsa:332 |
| PharmGKB ID(s) | PA25362 |
| General Description of Recombinant Human Survivin / BIRC5 / API4 Protein. | |
| Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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