PDF DatasheetRat CAMK4 / CaMKIV Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant CAMK4 / CaMKIV based upon sequence from Rat
Host: QP5752 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Rattus norvegicus (Rat) CAMK4 / CaMKIV, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5752.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Tyr474
Amino Acid Sequence: MLKVTVPSCP SSPCSSVTSS TENLVPDYWI DGSKRDPLSD FFEVESELGR GATSIVYRCK QKGTQKPYAL KVLKKTVDKK IVRTEIGVLL RLSHPNIIKL KEIFETPTEI SLVLELVTGG ELFDRIVEKG YYSERDAADA VKQILEAVAY LHENGIVHRD LKPENLLYAT PAPDAPLKIA DFGLSKIVEH QVLMKTVCGT PGYCAPEILR GCAYGPEVDM WSVGIITYIL LCGFEPFYDE RGDQFMFRRI LNCEYYFISP WWDEVSLNAK DLVKKLIVLD PKKRLTTFQA LQHPWVTGKA ANFVHMDTAQ KKLQEFNARR KLKAAVKAVV ASSRLGSASS SHTNIQESNK ASSEAQPAQD GKDKTDPLEN KMQAGDHEAA KAAADETMKL QSEEVEEEEG VKEEEEEEEE EEETSRMVPQ EPEDRLETDD QEMKRNSEET LKSVEEEMDP KAEEEAAAVG LGVPPQQDAI LPEY
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Rat CAMK4 / CaMKIV Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Rat CAMK4 / CaMKIV Protein General Information | |
|---|---|
| Alternate Names | |
| CAMK4, CaMKIV, AI666733, D18Bwg0362e, CaMKIV, CaMKIV/Gr, A430110E23Rik | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Camk4 |
| Entrez Gene ID | 25050 |
| Ensemble Gene ID | ENSRNOG00000020478 |
| RefSeq Protein Accession(s) | NP_036859.2 |
| RefSeq mRNA Accession(s) | NM_012727.3, XM_017600851.1 |
| UniProt ID(s) | P13234 |
| UniGene ID(s) | Rn.11046 |
| COSMIC ID Link(s) | Camk4 |
| KEGG Gene ID(s) | rno:25050 |
| General Description of Recombinant Rat CAMK4 / CaMKIV Protein. | |
| Isoform 1: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and mory consolidation. In the thymus, regulates the CD4+/CD8+ double positive thymocytes selection threshold during T-cell ontogeny. In CD4 mory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of tporal expression of BCL2. Phosphorylates the transcription activator CREB1 on ‘Ser-133’ in hippocampal neuron nuclei and contribute to mory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18 .Isoform 2: Heat-stable, acidic, calmodulin-binding protein. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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