PDF DatasheetHuman Caspase-14 / CASP14 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Caspase-14 / CASP14 based upon sequence from Human
Host: QP5761 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Caspase-14 / CASP14, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5761.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Lys153 – Tyr240
Amino Acid Sequence: KDSPQTIPTY TDALHVYSTV EGYIAYRHDQ KGSCFIQTLV DVFTKRKGHI LELLTEVTRR MAEAELVQEG KARKTNPEIQ STLRKRLY
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Caspase-14 / CASP14 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Caspase-14 / CASP14 Protein General Information | |
|---|---|
| Alternate Names | |
| Caspase-14, CASP14 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CASP14 |
| Entrez Gene ID | 23581 |
| Ensemble Gene ID | ENSG00000105141 |
| RefSeq Protein Accession(s) | NP_036246.1 |
| RefSeq mRNA Accession(s) | NM_012114.2 |
| UniProt ID(s) | P31944 |
| UniGene ID(s) | Hs.466057 |
| HGNC ID(s) | HGNC:1502 |
| COSMIC ID Link(s) | CASP14 |
| KEGG Gene ID(s) | hsa:23581 |
| PharmGKB ID(s) | PA26085 |
| General Description of Recombinant Human Caspase-14 / CASP14 Protein. | |
| Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum . Ses to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin . In vitro has a preference for the substate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF . Involved in processing of prosaposin in the epidermis . May be involved in retinal pigment epithelium cell barrier function . Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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