PDF DatasheetHuman Chromobox protein homolog 7 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Chromobox protein homolog 7 based upon sequence from Human
Host: QP5769 protein expressed in E.coli, Yeast..
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Chromobox protein homolog 7, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5769.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Phe251
Amino Acid Sequence: MELSAIGEQV FAVESIRKKR VRKGKVEYLV KWKGWPPKYS TWEPEEHILD PRLVMAYEEK EERDRASGYR KRGPKPKRLL LQRLYSMDLR SSHKAKGKEK LCFSLTCPLG SGSPEGVVKA GAPELVDKGP LVPTLPFPLR KPRKAHKYLR LSRKKFPPRG PNLESHSHRR ELFLQEPPAP DVLQAAGEWE PAAQPPEEEA DADLAEGPPP WTPALPSSEV TVTDITANSI TVTFREAQAA EGFFRDRSGK F
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Chromobox protein homolog 7 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Chromobox protein homolog 7 Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CBX7 |
| Entrez Gene ID | 23492 |
| Ensemble Gene ID | ENSG00000100307 |
| RefSeq Protein Accession(s) | NP_783640.1 |
| RefSeq mRNA Accession(s) | NM_175709.4 |
| UniProt ID(s) | O95931 |
| UniGene ID(s) | Hs.356416 |
| HGNC ID(s) | HGNC:1557 |
| COSMIC ID Link(s) | CBX7 |
| KEGG Gene ID(s) | hsa:23492 |
| PharmGKB ID(s) | PA26132 |
| General Description of Recombinant Human Chromobox protein homolog 7 Protein. | |
| Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin rodeling and modification of histones; it mediates monoubiquitination of histone H2A ‘Lys-119’, rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at ‘Lys-9’ (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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