PDF DatasheetHuman G1 / S-specific cyclin-D3 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant G1 / S-specific cyclin-D3 based upon sequence from Human
Host: QP5778 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) G1/S-specific cyclin-D3, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5778.
Bioactivity Data: Untested
Full Length? Full Length
Amino Acid Sequence: MELLCCEGTR HAPRAGPDPR LLGDQRVLQS LLRLEERYVP RASYFQCVQR EIKPHMRKML AYWMLEVCEE QRCEEEVFPL AMNYLDRYLS CVPTRKAQLQ LLGAVCMLLA SKLRETTPLT IEKLCIYTDH AVSPRQLRDW EVLVLGKLKW DLAAVIAHDF LAFILHRLSL PRDRQALVKK HAQTFLALCA TDYTFAMYPP SMIATGSIGA AVQGLGACSM SGDELTELLA GITGTEVDCL RACQEQIEAA LRESLREASQ TSSSPAPKAP RGSSSQGPSQ TSTPTDVTAI HL
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human G1 / S-specific cyclin-D3 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human G1 / S-specific cyclin-D3 Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CCND3 |
| Entrez Gene ID | 896 |
| Ensemble Gene ID | ENSG00000112576 |
| RefSeq Protein Accession(s) | NP_001129489.1 |
| RefSeq mRNA Accession(s) | NM_001136017.3, NM_001136125.2, NM_001136126.2, NM_001287427.1, NM_001287434.1, NM_001760.4 |
| UniProt ID(s) | P30281 |
| UniGene ID(s) | Hs.534307 |
| HGNC ID(s) | HGNC:1585 |
| COSMIC ID Link(s) | CCND3 |
| KEGG Gene ID(s) | hsa:896 |
| PharmGKB ID(s) | PA26152 |
| General Description of Recombinant Human G1 / S-specific cyclin-D3 Protein. | |
| Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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