PDF DatasheetHuman CD59 / CD59A / MAC-IP Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant CD59 / CD59A / MAC-IP based upon sequence from Human
Host: QP5791 protein expressed in E.coli, Yeast..
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) CD59 / CD59A / MAC-IP, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5791.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Leu26 – Asn102
Amino Acid Sequence: LQCYNCPNPT ADCKTAVNCS SDFDACLITK AGLQVYNKCW KFEHCNFNDV TTRLRENELT YYCCKKDLCN FNEQLEN
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human CD59 / CD59A / MAC-IP Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human CD59 / CD59A / MAC-IP Protein General Information | |
|---|---|
| Alternate Names | |
| CD59, CD59A, MAC-IP, HRF20, MIC11, MSK21, p18-20, EJ30, MEM43, MIN2, MIRL, 16.3A5, 1F5, EJ16, MAC-IP, HRF-20, MACIF, EL32, MIN1, MIN3, G344 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CD59 |
| Entrez Gene ID | 966 |
| Ensemble Gene ID | ENSG00000085063 |
| RefSeq Protein Accession(s) | NP_000602.1 |
| RefSeq mRNA Accession(s) | NM_000611.5, NM_001127223.1, NM_001127225.1, NM_001127226.1, NM_001127227.1, NM_203329.2, NM_203330.2, NM_203331.2 |
| UniProt ID(s) | P13987 |
| UniGene ID(s) | Hs.278573 |
| HGNC ID(s) | HGNC:1689 |
| COSMIC ID Link(s) | CD59 |
| KEGG Gene ID(s) | hsa:966 |
| PharmGKB ID(s) | PA26228 |
| General Description of Recombinant Human CD59 / CD59A / MAC-IP Protein. | |
| Potent inhibitor of the complent mbrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complents of the assbling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.The soluble form from urine retains its specific complent binding activity, but exhibits greatly reduced ability to inhibit MAC assbly on cell mbranes. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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