PDF DatasheetHuman p21WAF1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant p21WAF1 based upon sequence from Human
Host: QP5807 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) p21WAF1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5807.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ser2 – Pro164
Amino Acid Sequence: SEPAGDVRQN PCGSKACRRL FGPVDSEQLS RDCDALMAGC IQEARERWNF DFVTETPLEG DFAWERVRGL GLPKLYLPTG PRRGRDELGG GRRPGTSPAL LQGTAEEDHV DLSLSCTLVP RSGEQAEGSP GGPGDSQGRK RRQTSMTDFY HSKRRLIFSK RKP
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human p21WAF1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human p21WAF1 Protein General Information | |
|---|---|
| Alternate Names | |
| p21WAF1, CIP1, CAP20, CDKN1, MDA-6, P21, SDI1, WAF1, p21CIP1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CDKN1A |
| Entrez Gene ID | 1026 |
| Ensemble Gene ID | ENSG00000124762 |
| RefSeq Protein Accession(s) | NP_000380.1 |
| RefSeq mRNA Accession(s) | NM_000389.4, NM_001220777.1, NM_001220778.1, NM_001291549.1, NM_078467.2 |
| UniProt ID(s) | P38936 |
| UniGene ID(s) | Hs.370771 |
| HGNC ID(s) | HGNC:1784 |
| COSMIC ID Link(s) | CDKN1A |
| KEGG Gene ID(s) | hsa:1026 |
| PharmGKB ID(s) | PA104 |
| General Description of Recombinant Human p21WAF1 Protein. | |
| May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assbly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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