PDF DatasheetHuman CHI3L1 / YKL40 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant CHI3L1 / YKL40 based upon sequence from Human
Host: QP5829 protein expressed in E. coli.
Tag: HIs-Myc
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) CHI3L1 / YKL40, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5829.
Bioactivity Data: Untested
Full Length? Full Length of Mature Protein
Expression Region: Tyr22 – Thr383
Amino Acid Sequence: YKLVCYYTSW SQYREGDGSC FPDALDRFLC THIIYSFANI SNDHIDTWEW NDVTLYGMLN TLKNRNPNLK TLLSVGGWNF GSQRFSKIAS NTQSRRTFIK SVPPFLRTHG FDGLDLAWLY PGRRDKQHFT TLIKEMKAEF IKEAQPGKKQ LLLSAALSAG KVTIDSSYDI AKISQHLDFI SIMTYDFHGA WRGTTGHHSP LFRGQEDASP DRFSNTDYAV GYMLRLGAPA SKLVMGIPTF GRSFTLASSE TGVGAPISGP GIPGRFTKEA GTLAYYEICD FLRGATVHRI LGQQVPYATK GNQWVGYDDQ ESVKSKVQYL KDRQLAGAMV WALDLDDFQG SFCGQDLRFP LTNAIKDALA AT
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human CHI3L1 / YKL40 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human CHI3L1 / YKL40 Protein General Information | |
|---|---|
| Alternate Names | |
| CHI3L1, YKL40, GP39, ASRT7, YYL-40, hCGP-39, CGP-39, YKL-40, YKL40, GP-39, HCGP-3P, HC-gp39 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CHI3L1 |
| Entrez Gene ID | 1116 |
| Ensemble Gene ID | ENSG00000133048 |
| RefSeq Protein Accession(s) | NP_001267.2 |
| RefSeq mRNA Accession(s) | NM_001276.2 |
| UniProt ID(s) | P36222 |
| UniGene ID(s) | Hs.382202 |
| HGNC ID(s) | HGNC:1932 |
| COSMIC ID Link(s) | CHI3L1 |
| KEGG Gene ID(s) | hsa:1116 |
| PharmGKB ID(s) | PA26463 |
| General Description of Recombinant Human CHI3L1 / YKL40 Protein. | |
| Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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