PDF DatasheetHuman Corticotropin-releasing factor receptor 1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Corticotropin-releasing factor receptor 1 based upon sequence from Human
Host: QP5867 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Corticotropin-releasing factor receptor 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5867.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Ser24 – Ile121
Amino Acid Sequence: SLQDQHCESL SLASNISGLQ CNASVDLIGT CWPRSPAGQL VVRPCPAFFY GVRYNTTNNG YRECLANGSW AARVNYSECQ EILNEEKKSK VHYHVAVI
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Corticotropin-releasing factor receptor 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Corticotropin-releasing factor receptor 1 Protein General Information | |
|---|---|
| Alternate Names | |
| MGC57346-CRHR1, CRF1, CRHR1L, CRF-R-1, CRF-R1, CRF-R, CRHR, CRH-R1, CRFR-1, CRFR1, CRH-R-1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CRHR1 |
| Entrez Gene ID | 104909134 |
| Ensemble Gene ID | ENSG00000120088 |
| RefSeq Protein Accession(s) | NP_001138618.1 |
| RefSeq mRNA Accession(s) | NM_001145146.1, NM_001145147.1, NM_001145148.1, NM_001256299.2, NM_001303016.1, NM_001303018.1, NM_004382.4 |
| UniProt ID(s) | P34998 |
| UniGene ID(s) | Hs.417628 |
| HGNC ID(s) | HGNC:2357 |
| COSMIC ID Link(s) | CRHR1 |
| KEGG Gene ID(s) | hsa:104909134 |
| PharmGKB ID(s) | PA26874 |
| General Description of Recombinant Human Corticotropin-releasing factor receptor 1 Protein. | |
| G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal bryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.