PDF DatasheetCat CSF1R / MCSF Receptor / CD115 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant CSF1R / MCSF Receptor / CD115 based upon sequence from Cat
Host: QP5875 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Felis catus (Cat) (Felis silvestris catus) CSF1R / MCSF Receptor / CD115, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5875.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: Val20 – Pro5
Amino Acid Sequence: VPVIQPSGPE LVVEPGTTVT LRCVGNGSVE WDGPISPHWN LDLDPPSSIL TTNNATFQNT GTYHCTEPGN PQGGNATIHL YVKDPARPWK VLAQEVTVLE GQDALLPCLL TDPALEAGVS LVRVRGRPVL RQTNYSFSPW HGFTIHKAKF IENHVYQCSA RVDGRTVTSM GIWLKVQKDI SGPATLTLEP AELVRIQGEA AQIVCSASNI DVNFDVSLRH GDTKLTISQQ SDFHDNRYQK VLTLNLDHVS FQDAGNYSCT ATNAWGNHSA SMVFRVVESA YLNLTSEQSL LQEVTVGEKV DLQVKVEAYP GLESFNWTYL GPFSDYQDKL DFVTIKDTYR YTSTLSLPRL KRSEAGRYSF LARNAGGQNA LTFELTLRYP PEVRVTMTLI NGSDTLLCEA SGYPQPSVTW VQCRSHTDRC DESAGLVLED SHSEVLSQVP FHEVIVHSLL AIGTLEHNRT YECRAFNSVG NSSQTFWPIS IGAHTQLPDE LLFTP
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Cat CSF1R / MCSF Receptor / CD115 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Feline CSF1R / MCSF Receptor / CD115 Protein General Information | |
|---|---|
| Alternate Names | |
| CSF1R, MCSF Receptor, CD115, C-FMS, HDLS, CSF-1R, FMS, CSFR, FIM2, M-CSF-R, CD115 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CSF1R |
| Entrez Gene ID | 493706 |
| RefSeq Protein Accession(s) | NP_001009231.1 |
| RefSeq mRNA Accession(s) | NM_001009231.1 |
| UniProt ID(s) | P13369 |
| COSMIC ID Link(s) | CSF1R |
| KEGG Gene ID(s) | fca:493706 |
| General Description of Recombinant Feline CSF1R / MCSF Receptor / CD115 Protein. | |
| Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hatopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and fale fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of mbrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family mbers, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family mbers STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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