PDF DatasheetMouse Transcriptional repressor CTCFL Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Transcriptional repressor CTCFL based upon sequence from Mouse
Host: QP5884 protein expressed in E.coli, Yeast..
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Mus musculus (Mouse) Transcriptional repressor CTCFL, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5884.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Lys636
Amino Acid Sequence: MAAAEVPVPS GYFTQIKEQK LKPGDLEEEK EEDGVQRVEA QEGVVKEVEA ENSCLLLEAR APVESDRRIL TLQTVHLESQ DVHLQGLGWL SVPHSEELSG TVPEAEGILQ LPSVLWLDPE PQLSLQHCVT VSIPEELYPP EELQRIHFHL LRENVLMAEE NPELTPDLDE STALKKPEED EKDQLPPQGE TDKREERLLL LEMKPKEGKD DEIVLTISHL SLEEQQDPPA ANQTSVPGAK AAKPKRRRQT KGKPQSFQCD TCPFTSSKLS TFNRHIKIHS NERPHLCHLC LKAFRTVTLL RNHVNTHTGT RPHKCRDCDM AFVTSGELVR HRRYKHTYEK PFKCSLCKYA SVEASKMKRH IRSHTGERPF QCCQCAYASR DSYKLKRHMR THSGEKPYEC PTCHVRFTQS GTMKIHIAQK HGENVPKYEC PHCATIIARK SDLRVHLRNL HSQSPEEMKC RYCPAGFHER YALIQHQRTH KNEKKFKCKQ CDYACKQERC LKAHMRMHTG EKPFSCLACN KHFRQKQLLT VHLRKYHDPN FVPNLHLCLK CDKRFSRWSN LQRHRKKCDP EHETLAPNKD RRPVTRTQAS EGEAGHKEGE PQCPGEQALG HQGEAAGSQS PDHGLTCEII FNMMDK
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Mouse Transcriptional repressor CTCFL Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Mouse Transcriptional repressor CTCFL Protein General Information | |
|---|---|
| Alternate Names | |
| Boris, OTTMUSG00000016680 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Ctcfl |
| Entrez Gene ID | 664799 |
| Ensemble Gene ID | ENSMUSG00000070495 |
| RefSeq Protein Accession(s) | NP_001074856.1 |
| RefSeq mRNA Accession(s) | NM_001081387.2, XM_017319168.1 |
| UniProt ID(s) | A2APF3 |
| UniGene ID(s) | Mm.389396 |
| COSMIC ID Link(s) | Ctcfl |
| KEGG Gene ID(s) | mmu:664799 |
| General Description of Recombinant Mouse Transcriptional repressor CTCFL Protein. | |
| Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 ‘Arg-3’ to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites. Ses to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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