PDF DatasheetHuman DHDDS Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant DHDDS based upon sequence from Human
Host: QP5932 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) DHDDS, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5932.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Ala333
Amino Acid Sequence: MSWIKEGELS LWERFCANII KAGPMPKHIA FIMDGNRRYA KKCQVERQEG HSQGFNKLAE TLRWCLNLGI LEVTVYAFSI ENFKRSKSEV DGLMDLARQK FSRLMEEKEK LQKHGVCIRV LGDLHLLPLD LQELIAQAVQ ATKNYNKCFL NVCFAYTSRH EISNAVREMA WGVEQGLLDP SDISESLLDK CLYTNRSPHP DILIRTSGEV RLSDFLLWQT SHSCLVFQPV LWPEYTFWNL FEAILQFQMN HSVLQKARDM YAEERKRQQL ERDQATVTEQ LLREGLQASG DAQLRRTRLH KLSARREERV QGFLQALELK RADWLARLGT ASA
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human DHDDS Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human DHDDS Protein General Information | |
|---|---|
| Alternate Names | |
| CPT, HDS, RP59, DS, CIT, Dehydrodolichyl diphosphate synthase complex subunit DHD | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | DHDDS |
| Entrez Gene ID | 79947 |
| Ensemble Gene ID | ENSG00000117682 |
| RefSeq Protein Accession(s) | NP_001230493.1 |
| RefSeq mRNA Accession(s) | NM_001243564.1, NM_001243565.1, NM_024887.3, NM_205861.2, XM_006710912.2, XM_006710913.2, XM_006710914.2, XM_011542183.2, XM_011542184.2, XM_011542186.2, XM_017002379.1, XM_017002380.1 |
| UniProt ID(s) | Q86SQ9 |
| UniGene ID(s) | Hs.369385 |
| HGNC ID(s) | HGNC:20603 |
| COSMIC ID Link(s) | DHDDS |
| KEGG Gene ID(s) | hsa:79947 |
| PharmGKB ID(s) | PA134867119 |
| General Description of Recombinant Human DHDDS Protein. | |
| With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precusrosor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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