PDF DatasheetHuman Dihydrofolate reductase Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Dihydrofolate reductase based upon sequence from Human
Host: QP5933 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Dihydrofolate reductase, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5933.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Val2 – Asp187
Amino Acid Sequence: VGSLNCIVAV SQNMGIGKNG DLPWPPLRNE FRYFQRMTTT SSVEGKQNLV IMGKKTWFSI PEKNRPLKGR INLVLSRELK EPPQGAHFLS RSLDDALKLT EQPELANKVD MVWIVGGSSV YKEAMNHPGH LKLFVTRIMQ DFESDTFFPE IDLEKYKLLP EYPGVLSDVQ EEKGIKYKFE VYEKND
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Dihydrofolate reductase Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Dihydrofolate reductase Protein General Information | |
|---|---|
| Alternate Names | |
| DHFRP1, DYR | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | DHFR |
| Entrez Gene ID | 1719 |
| Ensemble Gene ID | ENSG00000228716 |
| RefSeq Protein Accession(s) | NP_000782.1 |
| RefSeq mRNA Accession(s) | NM_000791.3, NM_001290354.1 |
| UniProt ID(s) | P00374 |
| UniGene ID(s) | Hs.592364 |
| HGNC ID(s) | HGNC:2861 |
| COSMIC ID Link(s) | DHFR |
| KEGG Gene ID(s) | hsa:1719 |
| PharmGKB ID(s) | PA143 |
| General Description of Recombinant Human Dihydrofolate reductase Protein. | |
| Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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