PDF DatasheetHuman Transcription factor E2F6 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Transcription factor E2F6 based upon sequence from Human
Host: QP5958 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Transcription factor E2F6, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5958.
Bioactivity Data: Untested
Full Length? Full Length
Amino Acid Sequence: MSQQRPARKL PSLLLDPTEE TVRRRCRDPI NVEGLLPSKI RINLEDNVQY VSMRKALKVK RPRFDVSLVY LTRKFMDLVR SAPGGILDLN KVATKLGVRK RRVYDITNVL DGIDLVEKKS KNHIRWIGSD LSNFGAVPQQ KKLQEELSDL SAMEDALDEL IKDCAQQLFE LTDDKENERL AYVTYQDIHS IQAFHEQIVI AVKAPAETRL DVPAPREDSI TVHIRSTNGP IDVYLCEVEQ GQTSNKRSEG VGTSSSESTH PEGPEEEENP QQSEELLEVS N
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Transcription factor E2F6 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Transcription factor E2F6 Protein General Information | |
|---|---|
| Alternate Names | |
| E2F-6 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | E2F6 |
| Entrez Gene ID | 1876 |
| Ensemble Gene ID | ENSG00000169016 |
| RefSeq Protein Accession(s) | NP_001265204.1 |
| RefSeq mRNA Accession(s) | NM_001278275.1, NM_001278276.1, NM_001278277.1, NM_001278278.1, NM_198256.3 |
| UniProt ID(s) | O75461 |
| UniGene ID(s) | Hs.603093 |
| HGNC ID(s) | HGNC:3120 |
| COSMIC ID Link(s) | E2F6 |
| KEGG Gene ID(s) | hsa:1876 |
| PharmGKB ID(s) | PA27578 |
| General Description of Recombinant Human Transcription factor E2F6 Protein. | |
| Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5′-TTTC[CG]CGC-3′. Has a preference for the 5′-TTTCCCGC-3′ E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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