PDF DatasheetRat Ephrin-A5 / EFNA5 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Ephrin-A5 / EFNA5 based upon sequence from Rat
Host: QP5966 protein expressed in E.coli, Yeast..
Tag: His
Protein Construction: A DNA sequence encoding the Rattus norvegicus (Rat) Ephrin-A5 / EFNA5, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5966.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Gln21 – Asn203
Amino Acid Sequence: QDPGSKVVAD RYAVYWNSSN PRFQRGDYHI DVCINDYLDV FCPHYEDSVP EDKTERYVLY MVNFDGYSAC DHTSKGFKRW ECNRPHSPNG PLKFSEKFQL FTPFSLGFEF RPGREYFYIS SAIPDNGRRS CLKLKVFVRP TNSCMKTIGV RDRVFDVNDK VENSLEPADD TVHESAEPSR GEN
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Rat Ephrin-A5 / EFNA5 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Rat Ephrin-A5 / EFNA5 Protein General Information | |
|---|---|
| Alternate Names | |
| Ephrin-A5, EFNA5, AV158822, AL-1, EFL-5, Ephrin-A5, LERK-7, RAGS, Epl7 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | EFNA5 |
| Entrez Gene ID | 116683 |
| RefSeq Protein Accession(s) | NP_446355.1 |
| RefSeq mRNA Accession(s) | NM_053903.1 |
| UniProt ID(s) | P97605 |
| UniGene ID(s) | Rn.10714 |
| COSMIC ID Link(s) | EFNA5 |
| KEGG Gene ID(s) | rno:116683 |
| General Description of Recombinant Rat Ephrin-A5 / EFNA5 Protein. | |
| Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like mbrane microdomain when bound to the Extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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