PDF DatasheetHuman EIF4EBP2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant EIF4EBP2 based upon sequence from Human
Host: QP5973 protein expressed in E.coli, Yeast..
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) EIF4EBP2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5973.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Ile120
Amino Acid Sequence: MSSSAGSGHQ PSQSRAIPTR TVAISDAAQL PHDYCTTPGG TLFSTTPGGT RIIYDRKFLL DRRNSPMAQT PPCHLPNIPG VTSPGTLIED SKVEVNNLNN LNNHDRKHAV GDDAQFEMDI
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human EIF4EBP2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human EIF4EBP2 Protein General Information | |
|---|---|
| Alternate Names | |
| PHASII, 4EBP2, Eukaryotic translation initiation factor 4E-binding protein | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | EIF4EBP2 |
| Entrez Gene ID | 1979 |
| Ensemble Gene ID | ENSG00000148730 |
| RefSeq Protein Accession(s) | NP_004087.1 |
| RefSeq mRNA Accession(s) | NM_004096.4 |
| UniProt ID(s) | Q13542 |
| UniGene ID(s) | Hs.621200 |
| HGNC ID(s) | HGNC:3289 |
| COSMIC ID Link(s) | EIF4EBP2 |
| KEGG Gene ID(s) | hsa:1979 |
| PharmGKB ID(s) | PA27716 |
| General Description of Recombinant Human EIF4EBP2 Protein. | |
| Repressor of translation initiation involved in synaptic plasticity, learning and mory formation . Regulates EIF4E activity by preventing its assbly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation . EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal st cell renewal via its ability to repress translation initiation . Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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