Human EIF4EBP3 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant EIF4EBP3 based upon sequence from Human
Host: QP5974 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) EIF4EBP3, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5974.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Ile100
Amino Acid Sequence: MSTSTSCPIP GGRDQLPDCY STTPGGTLYA TTPGGTRIIY DRKFLLECKN SPIARTPPCC LPQIPGVTTP PTAPLSKLEE LKEQETEEEI PDDAQFEMDI
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human EIF4EBP3 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
Recombinant Human EIF4EBP3 Protein General Information | |
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Alternate Names | |
4EBP3, 4E-BP3, Eukaryotic translation initiation factor 4E-binding protein | |
Curated Database and Bioinformatic Data | |
Gene Symbol | EIF4EBP3 |
Entrez Gene ID | 8637 |
Ensemble Gene ID | ENSG00000243056 |
RefSeq Protein Accession(s) | NP_003723.1 |
RefSeq mRNA Accession(s) | NM_003732.2 |
UniProt ID(s) | O60516 |
UniGene ID(s) | Hs.594084 |
HGNC ID(s) | HGNC:3290 |
COSMIC ID Link(s) | EIF4EBP3 |
KEGG Gene ID(s) | hsa:8637 |
PharmGKB ID(s) | PA27718 |
General Description of Recombinant Human EIF4EBP3 Protein. | |
Repressor of translation initiation that regulates EIF4E activity by preventing its assbly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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