PDF DatasheetMouse Endoplasmic reticulum aminopeptidase 1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Endoplasmic reticulum aminopeptidase 1 based upon sequence from Mouse
Host: QP5992 protein expressed in E. coli.
Tag: His-Myc
Protein Construction: A DNA sequence encoding the Mus musculus (Mouse) Endoplasmic reticulum aminopeptidase 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5992.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Pro731 – Leu930
Amino Acid Sequence: PCVQRAERYF REWKSSNGNM SIPIDVTLAV FAVGAQNTEG WDFLYSKYQS SLSSTEKSQI EFSLCTSKDP EKLQWLLDQS FKGEIIKTQE FPHILTLIGR NPVGYPLAWK FLRENWNKLV QKFELGSSSI AHMVMGTTDQ FSTRARLEEV KGFFSSLKEN GSQLRCVQQT IETIEENIRW MDKNFDKIRL WLQKEKPELL
Purity: Greater than 80.6% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Mouse Endoplasmic reticulum aminopeptidase 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Mouse Endoplasmic reticulum aminopeptidase 1 Protein General Information | |
|---|---|
| Alternate Names | |
| ERAAP, Arts1, PILSAP, PILSA | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Erap1 |
| Entrez Gene ID | 80898 |
| Ensemble Gene ID | ENSMUSG00000021583 |
| RefSeq Protein Accession(s) | NP_109636.1 |
| RefSeq mRNA Accession(s) | NM_030711.4, XM_006517476.3 |
| UniProt ID(s) | Q9EQH2 |
| UniGene ID(s) | Mm.83526 |
| COSMIC ID Link(s) | Erap1 |
| KEGG Gene ID(s) | mmu:80898 |
| General Description of Recombinant Mouse Endoplasmic reticulum aminopeptidase 1 Protein. | |
| Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney (By similarity). | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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