PDF DatasheetHuman Estrogen Receptor 2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Estrogen Receptor 2 based upon sequence from Human
Host: QP6000 protein expressed in E.coli, Yeast..
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Estrogen Receptor 2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6000.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Asp2 – Gln530
Amino Acid Sequence: DIKNSPSSLN SPSSYNCSQS ILPLEHGSIY IPSSYVDSHH EYPAMTFYSP AVMNYSIPSN VTNLEGGPGR QTTSPNVLWP TPGHLSPLVV HRQLSHLYAE PQKSPWCEAR SLEHTLPVNR ETLKRKVSGN RCASPVTGPG SKRDAHFCAV CSDYASGYHY GVWSCEGCKA FFKRSIQGHN DYICPATNQC TIDKNRRKSC QACRLRKCYE VGMVKCGSRR ERCGYRLVRR QRSADEQLHC AGKAKRSGGH APRVRELLLD ALSPEQLVLT LLEAEPPHVL ISRPSAPFTE ASMMMSLTKL ADKELVHMIS WAKKIPGFVE LSLFDQVRLL ESCWMEVLMM GLMWRSIDHP GKLIFAPDLV LDRDEGKCVE GILEIFDMLL ATTSRFRELK LQHKEYLCVK AMILLNSSMY PLVTATQDAD SSRKLAHLLN AVTDALVWVI AKSGISSQQQ SMRLANLLML LSHVRHASNK GMEHLLNMKC KNVVPVYDLL LEMLNAHVLR GCKSSITGSE CSPAEDSKSK EGSQNPQSQ
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Estrogen Receptor 2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Estrogen Receptor 2 Protein General Information | |
|---|---|
| Alternate Names | |
| Estrogen Receptor 2, ESR-BETA, NR3A2, ESTRB, Erb, ESRB, ER-BETA | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ESR2 |
| Entrez Gene ID | 2100 |
| Ensemble Gene ID | ENSG00000140009 |
| RefSeq Protein Accession(s) | NP_001035365.1 |
| RefSeq mRNA Accession(s) | NM_001040275.1, NM_001214902.1, NM_001271876.1, NM_001271877.1, NM_001291712.1, NM_001291723.1, NM_001437.2, XM_017021079.1, XM_017021080.1, XM_017021081.1, XM_017021082.1, XM_017021083.1, XM_017021084.1 |
| UniProt ID(s) | Q92731 |
| UniGene ID(s) | Hs.660607 |
| HGNC ID(s) | HGNC:3468 |
| COSMIC ID Link(s) | ESR2 |
| KEGG Gene ID(s) | hsa:2100 |
| PharmGKB ID(s) | PA27886 |
| General Description of Recombinant Human Estrogen Receptor 2 Protein. | |
| Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elents (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated tperature is more gradual. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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