PDF DatasheetHuman ETHE1 / HSCO Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant ETHE1 / HSCO based upon sequence from Human
Host: QP6004 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) ETHE1 / HSCO, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6004.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Val8 – Ala254
Amino Acid Sequence: VARRQLSQRG GSGAPILLRQ MFEPVSCTFT YLLGDRESRE AVLIDPVLET APRDAQLIKE LGLRLLYAVN THCHADHITG SGLLRSLLPG CQSVISRLSG AQADLHIEDG DSIRFGRFAL ETRASPGHTP GCVTFVLNDH SMAFTGDALL IRGCGRTDFQ QGCAKTLYHS VHEKIFTLPG DCLIYPAHDY HGFTVSTVEE ERTLNPRLTL SCEEFVKIMG NLNLPKPQQI DFAVPANMRC GVQTPTA
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human ETHE1 / HSCO Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human ETHE1 / HSCO Protein General Information | |
|---|---|
| Alternate Names | |
| ETHE1, HSCO, HSCO, YF13H12 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ETHE1 |
| Entrez Gene ID | 23474 |
| Ensemble Gene ID | ENSG00000105755 |
| RefSeq Protein Accession(s) | NP_001307796.1 |
| RefSeq mRNA Accession(s) | NM_001320867.1, NM_001320868.1, NM_001320869.1, NM_014297.4, XM_005258687.3 |
| UniProt ID(s) | O95571 |
| UniGene ID(s) | Hs.7486 |
| HGNC ID(s) | HGNC:23287 |
| COSMIC ID Link(s) | ETHE1 |
| KEGG Gene ID(s) | hsa:23474 |
| PharmGKB ID(s) | PA134879650 |
| General Description of Recombinant Human ETHE1 / HSCO Protein. | |
| Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H2S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H2S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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