PDF DatasheetHuman Eyes absent homolog 2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Eyes absent homolog 2 based upon sequence from Human
Isoform: Isoform 2
Host: QP6005 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Eyes absent homolog 2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6005.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details). of Isoform 2
Expression Region: Met1 – Leu514
Amino Acid Sequence: MVELVISPSL TVNSDCLDKL KFNRADAAVW TLSDRQGITK SAPLRVSQLF SRSCPRVLPR QPSTAMAAYG QTQYSAGIQQ ATPYTAYPPP AQAYGIPSFS TSPTGQSPYT YQMHGTTGFY QGGNGLGNAA GFGSVHQDYP SYPGFPQSQY PQYYGSSYNP PYVPASSICP SPLSTSTYVL QEASHNVPNQ SSESLAGEYN THNGPSTPAK EGDTDRPHRA SDGKLRGRSK RSSDPSPAGD NEIERVFVWD LDETIIIFHS LLTGTFASRY GKDTTTSVRI GLMMEEMIFN LADTHLFFND LEDCDQIHVD DVSSDDNGQD LSTYNFSADG FHSSAPGANL CLGSGVHGGV DWMRKLAFRY RRVKEMYNTY KNNVGGLIGT PKRETWLQLR AELEALTDLW LTHSLKALNL INSRPNCVNV LVTTTQLIPA LAKVLLYGLG SVFPIENIYS ATKTGKESCF ERIMQRFGRK AVYVVIGDGV EEEQGAKKHN MPFWRISCHA DLEALRHALE LEYL
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Eyes absent homolog 2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Eyes absent homolog 2 Protein General Information | |
|---|---|
| Alternate Names | |
| EAB1 | |
| Molecular Weight | |
| Isoform 2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | EYA2 |
| Entrez Gene ID | 2139 |
| Ensemble Gene ID | ENSG00000064655 |
| RefSeq Protein Accession(s) | NP_005235.3 |
| RefSeq mRNA Accession(s) | NM_005244.4, NM_172110.3 |
| UniProt ID(s) | O00167 |
| UniGene ID(s) | Hs.472877 |
| HGNC ID(s) | HGNC:3520 |
| COSMIC ID Link(s) | EYA2 |
| KEGG Gene ID(s) | hsa:2139 |
| PharmGKB ID(s) | PA27932 |
| General Description of Recombinant Human Eyes absent homolog 2 Protein. | |
| Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates ‘Tyr-142’ of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. ‘Tyr-142’ phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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