PDF DatasheetHuman Fructose-1,6-bisphosphatase 1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Fructose-1,6-bisphosphatase 1 based upon sequence from Human
Host: QP6023 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Fructose-1,6-bisphosphatase 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6023.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ala1 – Gln338
Amino Acid Sequence: ADQAPFDTDV NTLTRFVMEE GRKARGTGEL TQLLNSLCTA VKAISSAVRK AGIAHLYGIA GSTNVTGDQV KKLDVLSNDL VMNMLKSSFA TCVLVSEEDK HAIIVEPEKR GKYVVCFDPL DGSSNIDCLV SVGTIFGIYR KKSTDEPSEK DALQPGRNLV AAGYALYGSA TMLVLAMDCG VNCFMLDPAI GEFILVDKDV KIKKKGKIYS LNEGYARDFD PAVTEYIQRK KFPPDNSAPY GARYVGSMVA DVHRTLVYGG IFLYPANKKS PNGKLRLLYE CNPMAYVMEK AGGMATTGKE AVLDVIPTDI HQRAPVILGS PDDVLEFLKV YEKHSAQ
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Fructose-1,6-bisphosphatase 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Fructose-1,6-bisphosphatase 1 Protein General Information | |
|---|---|
| Alternate Names | |
| FBP | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | FBP1 |
| Entrez Gene ID | 2203 |
| Ensemble Gene ID | ENSG00000165140 |
| RefSeq Protein Accession(s) | NP_000498.2 |
| RefSeq mRNA Accession(s) | NM_000507.3, NM_001127628.1 |
| UniProt ID(s) | P09467 |
| UniGene ID(s) | Hs.494496 |
| HGNC ID(s) | HGNC:3606 |
| COSMIC ID Link(s) | FBP1 |
| KEGG Gene ID(s) | hsa:2203 |
| PharmGKB ID(s) | PA28018 |
| General Description of Recombinant Human Fructose-1,6-bisphosphatase 1 Protein. | |
| Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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