PDF DatasheetHuman Fibrinogen beta chain Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Fibrinogen beta chain based upon sequence from Human
Host: QP6035 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Fibrinogen beta chain, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6035.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Gly45 – Gln491
Amino Acid Sequence: GHRPLDKKRE EAPSLRPAPP PISGGGYRAR PAKAAATQKK VERKAPDAGG CLHADPDLGV LCPTGCQLQE ALLQQERPIR NSVDELNNNV EAVSQTSSSS FQYMYLLKDL WQKRQKQVKD NENVVNEYSS ELEKHQLYID ETVNSNIPTN LRVLRSILEN LRSKIQKLES DVSAQMEYCR TPCTVSCNIP VVSGKECEEI IRKGGETSEM YLIQPDSSVK PYRVYCDMNT ENGGWTVIQN RQDGSVDFGR KWDPYKQGFG NVATNTDGKN YCGLPGEYWL GNDKISQLTR MGPTELLIEM EDWKGDKVKA HYGGFTVQNE ANKYQISVNK YRGTAGNALM DGASQLMGEN RTMTIHNGMF FSTYDRDNDG WLTSDPRKQC SKEDGGGWWY NRCHAANPNG RYYWGGQYTW DMAKHGTDDG VVWMNWKGSW YSMRKMSMKI RPFFPQQ
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Fibrinogen beta chain Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Fibrinogen beta chain Protein General Information | |
|---|---|
| Alternate Names | |
| HEL-S-78p | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | FGB |
| Entrez Gene ID | 2244 |
| Ensemble Gene ID | ENSG00000171564 |
| RefSeq Protein Accession(s) | NP_001171670.1 |
| RefSeq mRNA Accession(s) | NM_001184741.1, NM_005141.4 |
| UniProt ID(s) | P02675 |
| UniGene ID(s) | Hs.300774 |
| HGNC ID(s) | HGNC:3662 |
| COSMIC ID Link(s) | FGB |
| KEGG Gene ID(s) | hsa:2244 |
| PharmGKB ID(s) | PA163 |
| General Description of Recombinant Human Fibrinogen beta chain Protein. | |
| Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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