PDF DatasheetHuman FGFR3 / CD333 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant FGFR3 / CD333 based upon sequence from Human
Host: QP6047 protein expressed in E.coli, Yeast..
Tag: His-B2M
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) FGFR3 / CD333, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6047.
Bioactivity Data: Untested
Full Length? Cytoplasmic Domain
Expression Region: Arg397 – Thr806
Amino Acid Sequence: RLRSPPKKGL GSPTVHKISR FPLKRQVSLE SNASMSSNTP LVRIARLSSG EGPTLANVSE LELPADPKWE LSRARLTLGK PLGEGCFGQV VMAEAIGIDK DRAAKPVTVA VKMLKDDATD KDLSDLVSEM EMMKMIGKHK NIINLLGACT QGGPLYVLVE YAAKGNLREF LRARRPPGLD YSFDTCKPPE EQLTFKDLVS CAYQVARGME YLASQKCIHR DLAARNVLVT EDNVMKIADF GLARDVHNLD YYKKTTNGRL PVKWMAPEAL FDRVYTHQSD VWSFGVLLWE IFTLGGSPYP GIPVEELFKL LKEGHRMDKP ANCTHDLYMI MRECWHAAPS QRPTFKQLVE DLDRVLTVTS TDEYLDLSAP FEQYSPGGQD TPSSSSSGDD SVFAHDLLPP APPSSGGSRT
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human FGFR3 / CD333 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human FGFR3 / CD333 Protein (397-806aa) General Information | |
|---|---|
| Alternate Names | |
| FGFR3, CD333, FR3, Mfr3, CD333, Fgfr-3, HBGFR, Flg-2, sam3 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | FGFR3 |
| Entrez Gene ID | 2261 |
| Ensemble Gene ID | ENSG00000068078 |
| RefSeq Protein Accession(s) | NP_000133.1 |
| RefSeq mRNA Accession(s) | NM_000142.4, NM_001163213.1, NM_022965.3 |
| UniProt ID(s) | P22607 |
| UniGene ID(s) | Hs.1420 |
| HGNC ID(s) | HGNC:3690 |
| COSMIC ID Link(s) | FGFR3 |
| KEGG Gene ID(s) | hsa:2261 |
| PharmGKB ID(s) | PA28129 |
| General Description of Recombinant Human FGFR3 / CD333 Protein (397-806aa). | |
| Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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