PDF DatasheetHuman Forkhead box protein P1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Forkhead box protein P1 based upon sequence from Human
Host: QP6055 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Forkhead box protein P1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6055.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 – Gln114
Amino Acid Sequence: MMQESGTETK SNGSAIQNGS GGSNHLLECG GLREGRSNGE TPAVDIGAAD LAHAQQQQQQ ALQVARQLLL QQQQQQQVSG LKSPKRNDKQ PALQVPVSVA MMTPQVITPQ QMQQ
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Forkhead box protein P1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Forkhead box protein P1 Protein General Information | |
|---|---|
| Alternate Names | |
| hFKH1B, 12CC4, HSPC215, MFH, QRF1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | FOXP1 |
| Entrez Gene ID | 27086 |
| Ensemble Gene ID | ENSG00000114861 |
| RefSeq Protein Accession(s) | NP_001012523.1 |
| RefSeq mRNA Accession(s) | NM_001012505.1, NM_001244808.1, NM_001244810.1, NM_001244812.1, NM_001244814.1, NM_001244815.1, NM_001244816.1, NM_032682.5, XM_006713102.2, XM_006713103.2, XM_006713104.2, XM_011533584.2, XM_011533585.2, XM_017006165.1, XM_017006166.1, XM_017006168.1 |
| UniProt ID(s) | Q9H334 |
| UniGene ID(s) | Hs.59368 |
| HGNC ID(s) | HGNC:3823 |
| COSMIC ID Link(s) | FOXP1 |
| KEGG Gene ID(s) | hsa:27086 |
| PharmGKB ID(s) | PA28241 |
| General Description of Recombinant Human Forkhead box protein P1 Protein. | |
| Transcriptional repressor . Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential . Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in bryonic st cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintainance of hair follicle st cell quiescence; the function probably involves regulation of FGF18 . Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis . Binds to CSF1R promoter elents and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes ses to involve NCOR2 as corepressor . Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization ses to implicate suppression of SA5B . Can negatively regulate androgen receptor signaling . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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