PDF DatasheetHuman Zinc finger protein GLI2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Zinc finger protein GLI2 based upon sequence from Human
Host: QP6088 protein expressed in E.coli, Yeast, Mammal..
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Zinc finger protein GLI2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6088.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Glu412 – Leu641
Amino Acid Sequence: EQLADLKEDL DRDDCKQEAE VVIYETNCHW EDCTKEYDTQ EQLVHHINNE HIHGEKKEFV CRWQACTREQ KPFKAQYMLV VHMRRHTGEK PHKCTFEGCS KAYSRLENLK THLRSHTGEK PYVCEHEGCN KAFSNASDRA KHQNRTHSNE KPYICKIPGC TKRYTDPSSL RKHVKTVHGP DAHVTKKQRN DVHLRTPLLK ENGDSEAGTE PGGPESTEAS STSQAVEDCL
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Zinc finger protein GLI2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Zinc finger protein GLI2 Protein General Information | |
|---|---|
| Alternate Names | |
| THP1, THP2, CJS, PHS2, HPE9 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | GLI2 |
| Entrez Gene ID | 2736 |
| Ensemble Gene ID | ENSG00000074047 |
| RefSeq Protein Accession(s) | NP_005261.2 |
| RefSeq mRNA Accession(s) | NM_005270.4 |
| UniProt ID(s) | P10070 |
| UniGene ID(s) | Hs.111867 |
| HGNC ID(s) | HGNC:4318 |
| COSMIC ID Link(s) | GLI2 |
| KEGG Gene ID(s) | hsa:2736 |
| PharmGKB ID(s) | PA28721 |
| General Description of Recombinant Human Zinc finger protein GLI2 Protein. | |
| Functions as transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992). Functions as transcriptional activator (PubMed:9557682, PubMed:19878745, PubMed:24311597). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856).By similarity1 Publication5 Publications Isoform 1, isoform 2, isoform 3 and isoform 4: Act as transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Bind to the DNA sequence 5′-GAACCACCCA-3′ which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). Are involved in the smoothened (SHH) signaling pathway (PubMed:18455992).3 Publications Isoform 5: Acts as a transcriptional repressor. |
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Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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