PDF DatasheetRat Gremlin 1 / GREM1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Gremlin 1 / GREM1 based upon sequence from Rat
Host: QP6118 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Rattus norvegicus (Rat) Gremlin 1 / GREM1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6118.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Lys25 – Asp184
Amino Acid Sequence: KKKGSQGAIP PPDKAQHNDS EQTQSPPQPG SRTRGRGQGR GTAMPGEEVL ESSQEALHVT ERKYLKRDWC KTQPLKQTIH EEGCNSRTII NRFCYGQCNS FYIPRHIRKE EGSFQSCSFC KPKKFTTMMV TLNCPELQPP TKKKRVTRVK QCRCISIDLD
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Rat Gremlin 1 / GREM1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Rat Gremlin 1 / GREM1 Protein General Information | |
|---|---|
| Alternate Names | |
| Gremlin 1, GREM1, Grem, Drm, Cktsf1b1, ld | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Grem1 |
| Entrez Gene ID | 50566 |
| Ensemble Gene ID | ENSRNOG00000026053 |
| RefSeq Protein Accession(s) | NP_062155.1 |
| RefSeq mRNA Accession(s) | NM_019282.3 |
| UniProt ID(s) | O35793 |
| UniGene ID(s) | Rn.42929 |
| COSMIC ID Link(s) | Grem1 |
| KEGG Gene ID(s) | rno:50566 |
| General Description of Recombinant Rat Gremlin 1 / GREM1 Protein. | |
| Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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