PDF DatasheetHuman Glutamate receptor 3 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Glutamate receptor 3 based upon sequence from Human
Host: QP6120 protein expressed in E.coli, Yeast..
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Glutamate receptor 3, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6120.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Ser151 – Leu250
Amino Acid Sequence: SLLGHYKWEK FVYLYDTERG FSILQAIMEA AVQNNWQVTA RSVGNIKDVQ EFRRIIEEMD RRQEKRYLID CEVERINTIL EQVVILGKHS RGYHYMLANL
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Glutamate receptor 3 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Glutamate receptor 3 Protein General Information | |
|---|---|
| Alternate Names | |
| GLURC, GLUR-C, GluA3, GLUR3, MRX94, GLUR-K3 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | GRIA3 |
| Entrez Gene ID | 2892 |
| Ensemble Gene ID | ENSG00000125675 |
| RefSeq Protein Accession(s) | NP_000819.3 |
| RefSeq mRNA Accession(s) | NM_000828.4, NM_007325.4 |
| UniProt ID(s) | P42263 |
| UniGene ID(s) | Hs.377070 |
| HGNC ID(s) | HGNC:4573 |
| COSMIC ID Link(s) | GRIA3 |
| KEGG Gene ID(s) | hsa:2892 |
| PharmGKB ID(s) | PA28968 |
| General Description of Recombinant Human Glutamate receptor 3 Protein. | |
| Receptor for glutamate that functions as ligand-gated ion channel in the central nervous syst and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous syst. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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