PDF DatasheetHuman Granzyme B / GZMB Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Granzyme B / GZMB based upon sequence from Human
Host: QP6136 protein expressed in E.coli, Yeast..
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Granzyme B / GZMB, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6136.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ile21 – Tyr247
Amino Acid Sequence: IIGGHEAKPH SRPYMAYLMI WDQKSLKRCG GFLIRDDFVL TAAHCWGSSI NVTLGAHNIK EQEPTQQFIP VKRPIPHPAY NPKNFSNDIM LLQLERKAKR TRAVQPLRLP SNKAQVKPGQ TCSVAGWGQT APLGKHSHTL QEVKMTVQED RKCESDLRHY YDSTIELCVG DPEIKKTSFK GDSGGPLVCN KVAQGIVSYG RNNGMPPRAC TKVSSFVHWI KKTMKRY
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Granzyme B / GZMB Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Granzyme B / GZMB Protein General Information | |
|---|---|
| Alternate Names | |
| Granzyme B, GZMB, CGL1, C11, CSP-B, CTSGL1, CCPI, CGL-1, CSPB, SECT, CTLA1, HLP | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | GZMB |
| Entrez Gene ID | 3002 |
| Ensemble Gene ID | ENSG00000100453 |
| RefSeq Protein Accession(s) | NP_004122.2 |
| RefSeq mRNA Accession(s) | NM_004131.5 |
| UniProt ID(s) | P10144 |
| UniGene ID(s) | Hs.1051 |
| HGNC ID(s) | HGNC:4709 |
| COSMIC ID Link(s) | GZMB |
| KEGG Gene ID(s) | hsa:3002 |
| General Description of Recombinant Human Granzyme B / GZMB Protein. | |
| This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Ses to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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