PDF DatasheetHuman HAND2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant HAND2 based upon sequence from Human
Isoform: Isoform 2
Host: QP6142 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) HAND2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6142.
Bioactivity Data: Untested
Full Length? Full Length of Isoform 2
Expression Region: Met1 – Gln180
Amino Acid Sequence: MSLVGGFPHH PVVHHEGYPF AAAAAASRCS HEENPYFHGW LIGHPEMSPP DYSMALSYSP EYASGTANRK ERRRTQSINS AFAELRECIP NVPADTKLSK IKTLRLATSY IAYLMDLLAK DDQNGEAEAF KAEIKKTDVK EEKRKKELNE ILKSTVSSND KKTKGRTGWP QHVWALELKQ
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human HAND2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human HAND2 Protein General Information | |
|---|---|
| Alternate Names | |
| DHAND2, Thing2, Hed, dHand, bHLHa26, Heart- and neural crest derivatives-expressed protein | |
| Molecular Weight | |
| Isoform 2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | HAND2 |
| Entrez Gene ID | 9464 |
| Ensemble Gene ID | ENSG00000164107 |
| RefSeq Protein Accession(s) | NP_068808.1 |
| RefSeq mRNA Accession(s) | NM_021973.2 |
| UniProt ID(s) | P61296 |
| UniGene ID(s) | Hs.388245 |
| HGNC ID(s) | HGNC:4808 |
| COSMIC ID Link(s) | HAND2 |
| KEGG Gene ID(s) | hsa:9464 |
| PharmGKB ID(s) | PA29184 |
| General Description of Recombinant Human HAND2 Protein. | |
| Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5′-CANNTG-3′ | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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