PDF DatasheetHuman HDAC8 / HDACL1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant HDAC8 / HDACL1 based upon sequence from Human
Host: QP6155 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) HDAC8 / HDACL1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6155.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Val377
Amino Acid Sequence: MEEPEEPADS GQSLVPVYIY SPEYVSMCDS LAKIPKRASM VHSLIEAYAL HKQMRIVKPK VASMEEMATF HTDAYLQHLQ KVSQEGDDDH PDSIEYGLGY DCPATEGIFD YAAAIGGATI TAAQCLIDGM CKVAINWSGG WHHAKKDEAS GFCYLNDAVL GILRLRRKFE RILYVDLDLH HGDGVEDAFS FTSKVMTVSL HKFSPGFFPG TGDVSDVGLG KGRYYSVNVP IQDGIQDEKY YQICESVLKE VYQAFNPKAV VLQLGADTIA GDPMCSFNMT PVGIGKCLKY ILQWQLATLI LGGGGYNLAN TARCWTYLTG VILGKTLSSE IPDHEFFTAY GPDYVLEITP SCRPDRNEPH RIQQILNYIK GNLKHVV
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human HDAC8 / HDACL1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human HDAC8 / HDACL1 Protein General Information | |
|---|---|
| Alternate Names | |
| HDAC8, HDACL1, RPD3, CDA07, CDLS5, HDACL1, MRXS6, WTS, HD8 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | HDAC8 |
| Entrez Gene ID | 55869 |
| Ensemble Gene ID | ENSG00000147099 |
| RefSeq Protein Accession(s) | NP_001159890.1 |
| RefSeq mRNA Accession(s) | NM_001166418.1, NM_001166419.1, NM_001166420.1, NM_001166422.1, NM_001166448.1, NM_018486.2 |
| UniProt ID(s) | Q9BY41 |
| UniGene ID(s) | Hs.310536 |
| HGNC ID(s) | HGNC:13315 |
| COSMIC ID Link(s) | HDAC8 |
| KEGG Gene ID(s) | hsa:55869 |
| PharmGKB ID(s) | PA37766 |
| General Description of Recombinant Human HDAC8 / HDACL1 Protein. | |
| Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.