PDF DatasheetMouse HSP70 / HSPA1A Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant HSP70 / HSPA1A based upon sequence from Mouse
Host: QP6185 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Mus musculus (Mouse) HSP70 / HSPA1A, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6185.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ala2 – Asp642
Amino Acid Sequence: AKNTAIGIDL GTTYSCVGVF QHGKVEIIAN DQGNRTTPSY VAFTDTERLI GDAAKNQVAL NPQNTVFDAK RLIGRKFGDA VVQSDMKHWP FQVVNDGDKP KVQVNYKGES RSFFPEEISS MVLTKMKEIA EAYLGHPVTN AVITVPAYFN DSQRQATKDA GVIAGLNVLR IINEPTAAAI AYGLDRTGKG ERNVLIFDLG GGTFDVSILT IDDGIFEVKA TAGDTHLGGE DFDNRLVSHF VEEFKRKHKK DISQNKRAVR RLRTACERAK RTLSSSTQAS LEIDSLFEGI DFYTSITRAR FEELCSDLFR GTLEPVEKAL RDAKMDKAQI HDLVLVGGST RIPKVQKLLQ DFFNGRDLNK SINPDEAVAY GAAVQAAILM GDKSENVQDL LLLDVAPLSL GLETAGGVMT ALIKRNSTIP TKQTQTFTTY SDNQPGVLIQ VYEGERAMTR DNNLLGRFEL SGIPPAPRGV PQIEVTFDID ANGILNVTAT DKSTGKANKI TITNDKGRLS KEEIERMVQE AERYKAEDEV QRDRVAAKNA LESYAFNMKS AVEDEGLKGK LSEADKKKVL DKCQEVISWL DSNTLADKEE FVHKREELER VCSPIISGLY QGAGAPGAGG FGAQAPPKGA SGSGPTIEEV D
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Mouse HSP70 / HSPA1A Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Mouse HSP70 / HSPA1A Protein General Information | |
|---|---|
| Alternate Names | |
| HSP70, HSPA1A, HSP70-1B, HSP70-2, HSP70.2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Hspa1b |
| Entrez Gene ID | 15511 |
| Ensemble Gene ID | ENSMUSG00000090877 |
| RefSeq Protein Accession(s) | NP_034608.2 |
| RefSeq mRNA Accession(s) | NM_010478.2 |
| UniProt ID(s) | P17879 |
| UniGene ID(s) | Mm.372314 |
| COSMIC ID Link(s) | Hspa1b |
| KEGG Gene ID(s) | mmu:15511 |
| General Description of Recombinant Mouse HSP70 / HSPA1A Protein. | |
| In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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