PDF DatasheetHuman DNA-binding protein inhibitor ID-2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant DNA-binding protein inhibitor ID-2 based upon sequence from Human
Host: QP6191 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) DNA-binding protein inhibitor ID-2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6191.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Gly134
Amino Acid Sequence: MKAFSPVRSV RKNSLSDHSL GISRSKTPVD DPMSLLYNMN DCYSKLKELV PSIPQNKKVS KMEILQHVID YILDLQIALD SHPTIVSLHH QRPGQNQASR TPLTTLNTDI SILSLQASEF PSELMSNDSK ALCG
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human DNA-binding protein inhibitor ID-2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human DNA-binding protein inhibitor ID-2 Protein General Information | |
|---|---|
| Alternate Names | |
| GIG8, ID2A, ID2H, bHLHb26 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ID2 |
| Entrez Gene ID | 3398 |
| Ensemble Gene ID | ENSG00000115738 |
| RefSeq Protein Accession(s) | NP_002157.2 |
| RefSeq mRNA Accession(s) | NM_002166.4 |
| UniProt ID(s) | Q02363 |
| UniGene ID(s) | Hs.180919 |
| HGNC ID(s) | HGNC:5361 |
| COSMIC ID Link(s) | ID2 |
| KEGG Gene ID(s) | hsa:3398 |
| PharmGKB ID(s) | PA29609 |
| General Description of Recombinant Human DNA-binding protein inhibitor ID-2 Protein. | |
| Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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