PDF DatasheetSheep IL12B / P40 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant IL12B / P40 based upon sequence from Sheep
Host: QP6210 protein expressed in E.coli, Yeast..
Tag: His
Protein Construction: A DNA sequence encoding the Ovis aries (Sheep) IL12B / P40, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6210.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ile23 – Ser327
Amino Acid Sequence: IWELEKNVYV VELDWYPNAP GETVVLTCDT PEEDGITWTS DQSSEVLGSG KTLTIQVKEF GDAGQYTCHK GGEVLSRSLL LLHKKEDGIW STDILKDQKE PKAKSFLKCE AKDYSGHFTC SWLTAISTNL KFSVKSSRGS SDPRGVTCGA ASLSAEKVSM DHREYNKYTV ECQEGSACPA AEESLPIEVV MEAVHKLKYE NYTSSFFIRD IIKPDPPKNL QLRPLKNSRQ VEVSWEYPDT WSTPHSYFSL TFCVQVQGKN KREKKLFTDQ TSAKVTCHKD ANIRVQARDR YYSSFWSEWA SVSCS
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Sheep IL12B / P40 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Sheep IL12B / P40 Protein General Information | |
|---|---|
| Alternate Names | |
| IL12B, P40, IMD29, CLMF2, CLMF, IL-12B, IMD28, NKSF, NKSF2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IL12B |
| Entrez Gene ID | 443472 |
| RefSeq Protein Accession(s) | NP_001009438.1 |
| RefSeq mRNA Accession(s) | NM_001009438.1 |
| UniProt ID(s) | P68220 |
| UniGene ID(s) | Oar.721 |
| COSMIC ID Link(s) | IL12B |
| KEGG Gene ID(s) | oas:443472 |
| General Description of Recombinant Sheep IL12B / P40 Protein. | |
| Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates mory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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