PDF DatasheetHuman Integrin alpha-IIb Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Integrin alpha-IIb based upon sequence from Human
Host: QP6239 protein expressed in E.coli, Yeast..
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Integrin alpha-IIb, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6239.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Cys639 – Arg887
Amino Acid Sequence: CVPQLQLTAS VTGSPLLVGA DNVLELQMDA ANEGEGAYEA ELAVHLPQGA HYMRALSNVE GFERLICNQK KENETRVVLC ELGNPMKKNA QIGIAMLVSV GNLEEAGESV SFQLQIRSKN SQNPNSKIVL LDVPVRAEAQ VELRGNSFPA SLVVAAEEGE REQNSLDSWG PKVEHTYELH NNGPGTVNGL HLSIHLPGQS QPSDLLYILD IQPQGGLQCF PQPPVNPLKV DWGLPIPSPS PIHPAHHKR
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Integrin alpha-IIb Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Integrin alpha-IIb Protein General Information | |
|---|---|
| Alternate Names | |
| BDPLT2, GTA, GPIIb, GT, BDPLT16, GP2B, CD41, HPA3, PPP1R93, CD41B | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ITGA2B |
| Entrez Gene ID | 3674 |
| Ensemble Gene ID | ENSG00000005961 |
| RefSeq Protein Accession(s) | NP_000410.2 |
| RefSeq mRNA Accession(s) | NM_000419.4, XM_011524749.1 |
| UniProt ID(s) | P08514 |
| UniGene ID(s) | Hs.411312 |
| HGNC ID(s) | HGNC:6138 |
| COSMIC ID Link(s) | ITGA2B |
| KEGG Gene ID(s) | hsa:3674 |
| PharmGKB ID(s) | PA29938 |
| General Description of Recombinant Human Integrin alpha-IIb Protein. | |
| Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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