PDF DatasheetHuman KCNAB2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant KCNAB2 based upon sequence from Human
Host: QP6252 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) KCNAB2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6252.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Ser367
Amino Acid Sequence: MYPESTTGSP ARLSLRQTGS PGMIYSTRYG SPKRQLQFYR NLGKSGLRVS CLGLGTWVTF GGQITDEMAE QLMTLAYDNG INLFDTAEVY AAGKAEVVLG NIIKKKGWRR SSLVITTKIF WGGKAETERG LSRKHIIEGL KASLERLQLE YVDVVFANRP DPNTPMEETV RAMTHVINQG MAMYWGTSRW SSMEIMEAYS VARQFNLTPP ICEQAEYHMF QREKVEVQLP ELFHKIGVGA MTWSPLACGI VSGKYDSGIP PYSRASLKGY QWLKDKILSE EGRRQQAKLK ELQAIAERLG CTLPQLAIAW CLRNEGVSSV LLGASNADQL MENIGAIQVL PKLSSSIIHE IDSILGNKPY SKKDYRS
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human KCNAB2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human KCNAB2 Protein General Information | |
|---|---|
| Alternate Names | |
| KCNA2B, HKvbeta2.2, HKvbeta2, AKR6A5, HKvbeta2.1, KV-BETA-2, Voltage-gated potassium channel subunit beta | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | KCNAB2 |
| Entrez Gene ID | 8514 |
| Ensemble Gene ID | ENSG00000069424 |
| RefSeq Protein Accession(s) | NP_001186789.1 |
| RefSeq mRNA Accession(s) | NM_001199860.1, NM_001199861.1, NM_001199862.1, NM_001199863.1, NM_003636.3, NM_172130.2, XM_005263514.2, XM_011542321.2, XM_011542322.2 |
| UniProt ID(s) | Q13303 |
| UniGene ID(s) | Hs.440497 |
| HGNC ID(s) | HGNC:6229 |
| COSMIC ID Link(s) | KCNAB2 |
| KEGG Gene ID(s) | hsa:8514 |
| PharmGKB ID(s) | PA373 |
| General Description of Recombinant Human KCNAB2 Protein. | |
| Cytoplasmic domain potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits . Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability . Promotes expression of the pore-forming alpha subunits at the cell mbrane, and thereby increases channel activity . Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore . Promotes KCNA4 channel closure . Modulates the functional properties of KCNA5 . Enhances KCNB2 channel activity . Binds NADPH and has NADPH-dependent aldoketoreductase activity . Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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