PDF DatasheetHuman KCNJ1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant KCNJ1 based upon sequence from Human
Host: QP6255 protein expressed in E.coli, Yeast..
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) KCNJ1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6255.
Bioactivity Data: Untested
Full Length? Cytoplasmic Domain
Expression Region: Ile178 – Met3
Amino Acid Sequence: ILAKISRPKK RAKTITFSKN AVISKRGGKL CLLIRVANLR KSLLIGSHIY GKLLKTTVTP EGETIILDQI NINFVVDAGN ENLFFISPLT IYHVIDHNSP FFHMAAETLL QQDFELVVFL DGTVESTSAT CQVRTSYVPE EVLWGYRFAP IVSKTKEGKY RVDFHNFSKT VEVETPHCAM CLYNEKDVRA RMKRGYDNPN FILSEVNETD DTKM
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human KCNJ1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human KCNJ1 Protein General Information | |
|---|---|
| Alternate Names | |
| ROMK, ROMK1, KIR1.1, ATP-sensitive inward rectifier potassium channel | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | KCNJ1 |
| Entrez Gene ID | 3758 |
| Ensemble Gene ID | ENSG00000151704 |
| RefSeq Protein Accession(s) | NP_000211.1 |
| RefSeq mRNA Accession(s) | NM_000220.4, NM_153764.2, NM_153765.2, NM_153766.2, NM_153767.3 |
| UniProt ID(s) | P48048 |
| UniGene ID(s) | Hs.527830 |
| HGNC ID(s) | HGNC:6255 |
| COSMIC ID Link(s) | KCNJ1 |
| KEGG Gene ID(s) | hsa:3758 |
| PharmGKB ID(s) | PA213 |
| General Description of Recombinant Human KCNJ1 Protein. | |
| In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of Extracellular domain potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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